Application of genomic surveillance to the field investigation of the first confirmed cases of the Gamma Lineage P.1 variant of SARS-CoV-2 virus of concern in Leticia, Colombia, 2021.
DOI:
https://doi.org/10.33610/01229907.2022v4n3a2Keywords:
COVID-19, SARS-CoV-2, Epidemiological surveillance, Viral genome, Genome sequencingAbstract
Introduction: The P.1 variant of SARS-CoV-2 is
considered a public health concern due to its high
transmissibility and interference with the host immune response. Through the genomic surveillance
strategy implemented in Colombia, the first three
cases of this variant were identified in Leticia,
Amazonas.
Objective: to characterize the first confirmed cases of the P.1 variant in Leticia, Amazonas, Colombia.
Methodology: Case study. The immediate response team was deployed to conduct the epidemiologic field investigation, medical record review, and
geo-referencing using Google Earth. Confirmed
cases of SARS-CoV-2 infection that were genetically sequenced and tested positive for the P.1
variant were included, and sociodemographic variables were analyzed.
Results: There were 3 confirmed positive cases of
COVID-19 lineage B.1.1.28. They were adults with
a mean age of 47 years, two females and one male.
Two cases were regular travelers to the city of Tabatinga, Brazil. The average incubation period was
9 days. The common symptom was fever; myalgias, arthralgias, cough, diarrhea, and respiratory
distress were also present. Two cases required
hospitalization, one of which was transferred to
the intensive care unit due to the need for invasive
ventilatory support, with a fatal outcome after 2
weeks.
Conclusions: The first three cases were identified
with variant P.1, unrelated to each other. One case
with deceased final condition. The P.1 variant was
under community circulation.
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